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Chamomile

SLEEP INGREDIENT

Chamomile

SLEEP INGREDIENT

INGREDIENT RESEARCH

Relaxation

Relaxation

Sleep Quality

Sleep Quality

WHAT SCIENCE SAYS:

Chamomile has long been used as a soothing remedy. Research demonstrates that there may be possible anti-anxiety benefits.

Chamomile has long been used as a soothing remedy. Research demonstrates that there may be possible anti-anxiety benefits.

FUN FACT

This herb has been used in teas for thousands of years to calm anxiety and settle stomachs.

This herb has been used in teas for thousands of years to calm anxiety and settle stomachs.

Evidence Based Facts

A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder

Jay D Amsterdam , Yimei Li, Irene Soeller, Kenneth Rockwell, Jun James Mao, Justine Shults
J Clin Psychopharmacol 2009 Aug;29(4):378-82.


PURPOSE:

We conducted a randomized, double-blind, placebo-controlled efficacy and tolerability trial of Matricaria recutita (chamomile) extract therapy in patients with mild to moderate generalized anxiety disorder (GAD). We hypothesized that chamomile would be superior to placebo in reducing GAD symptoms with a comparable tolerability profile.


METHODS:

Sixty-one outpatients with mild to moderate GAD were enrolled, and 57 were randomized to either double-blind chamomile extract (n = 28) or placebo therapy (n = 29) for 8 weeks. The study was powered to detect a statistically significant and clinically meaningful group difference in change over time in total Hamilton Anxiety Rating (HAM-A) scores. Secondary outcomes included change in the Beck Anxiety Inventory, Psychological Well Being, and Clinical Global Impression Severity scores and the proportion of patients with 50% reduction or more in baseline HAM-A score.


RESULTS:

We observed a significantly greater reduction in mean total HAM-A score during chamomile versus placebo therapy (P = 0.047). Although the study was not powered to identify small to moderate differences in secondary outcomes, we observed a positive change in all secondary outcomes in the same direction as the primary outcome measure. One patient in each treatment group discontinued therapy for adverse events. The proportion of patients experiencing 0, 1, 2, or 3 adverse events or more was not significantly different between groups (P = 0.417).


CONCLUSIONS:

Conclusions: This is the first controlled clinical trial of chamomile extract for GAD. The results suggest that chamomile may have modest anxiolytic activity in patients with mild to moderate GAD. Future studies are needed to replicate these observations.

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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